Evaluation of the Antiviral Activity of Monomeric, Dimeric, and Oligomeric Flavonoids against Chikungunya and Mayaro Viruses.

However, this is almost insignificant due to the washing step of the cell cultures in PBS buffer, after 1 h of viral adsorption, which removes most of the drug used in the treatment, thus remaining throughout the replication cycle.

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Nonetheless, this reduction remains highly significant and reinforces the relevance of procyanidins as promising candidate structures for preclinical candidates against emerging arboviruses.

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