Neuraminidase-Associated Vaginal Dysbiosis Correlates with HPV Infection Across Oncogenic Risk Subtypes.

In contrast, fungal infection showed a decreasing trend across groups (0.066, 0.045, 0.035, 0.051; p = 2.51 × 10 −6 ), consistent with its inverse association with HPV infection.

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The magnitude of association was particularly pronounced in possible-risk HPV (aOR ≈ 1.83), but remained highly significant in all models, suggesting that neuraminidase reflects a general permissive state of the vaginal microenvironment rather than a subtype-specific effect.

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