Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer.

Co-IF staining showed an increasing trend in CD8 + T-cell infiltration in 7940B tumors from Ccr1 −/− hosts, along with a significant increase in granzyme B staining, both in CD8 + cells (i.e., granzyme B + CD8 + T cells) and in CD8 − cells, possibly NK cells ( Fig. 4C , with quantification in 4D ; Supplementary Fig.

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