Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.

31 , 32 There is a highly significant correlation between CD69-positive B cells and the response to bortezomib combination therapy in multiple myeloma patients. 33 For this study, we locally administered bortezomib according to previous studies (Fig. 4a ). 34 , 35 Immunohistochemical analysis confirmed that bortezomib treatment markedly reduced IgM production in the alveolar bone exposed to orthodontic force (Fig. 4b, c ).

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