CCR1-mediated monocyte chemotaxis in the immunopathology of primary Sjögren's syndrome: multi-omics integration analysis and computational target prioritization implicating <i>Polygonatum odoratum</i>.

The distribution of subtypes along the pseudotime axis ( Figure 6H ) showed that classical monocytes had the lowest Pseudotime values (early differentiation), non-classical had the highest (late differentiation), with intermediate in between, and inter-subtype differences were highly significant (P < 0.0001), validating the biological plausibility of trajectory reconstruction.

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Although subtype proportions did not reach statistical significance between pSS and controls (classical P = 0.61, non-classical P = 0.61), intermediate monocytes showed an increasing trend (P = 0.073), consistent with previously reported intermediate monocyte expansion in inflammatory diseases ( 33 ).

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