Ivosidenib and Vorasidenib Decrease Intratumoral 2-Hydroxyglutarate and Total Choline Levels in Patients with Lower-Grade Glioma: An In Vivo MR Spectroscopy Study.

Clin Cancer Res · 2026 · PMC13430226 · PMID 41995710

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantP < 0.001actually significant

The decrease in 2HG levels was highly significant ( P < 0.001; r = 0.81) across patients undergoing therapy ( Fig. 3A ).

also in 132,142 other papers

a nonsignificant trendP = 0.1so close (0.05 < p ≤ 0.1)

There was also a nonsignificant trend toward an increase in tNAA ( P = 0.1, r = 0.45, Fig. 4 ).

also in 5,406 other papers

a decreasing trendno p-value reported

Gln also showed a decreasing trend; however, the decrease is significant only in oligodendroglioma ( P < 0.05; Cohen’s d = 1.50).

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.