Therapy-Associated Vitiligo: Hypopigmentation Secondary to Programmed Cell Death Protein 1 Inhibitors, Interferon Alfa-2b, Cytotoxic T-Lymphocyte-Associated Protein 4 Inhibitors, and B-Raf/Mitogen-Activated Protein Kinase Kinase Inhibitors.

Cureus · 2026 · PMC13431794 · PMID 42549405

Europe PMC DOI

hedged sentence

0.0009

closest p · 0.0× alpha

0.0009

boldest claim

The sentences

highly significantp<0.0009actually significant

The striking association with PD-1 inhibitors (RR: 24.84; 95% CI: 16.92-36.48), IFN-α2b (RR: 3.10; 95% CI: 1.53-6.30), and CTLA-4 inhibitors (RR: 32.042; 95% CI: 18.052-56.875) were all highly significant (p<0.0009), highlighting a consistent biological signal.

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