highly significantP < 0.00001
Pooled data from 13 distinct datasets (10 unique studies), including 415 FGR cases and 561 controls, demonstrated a marked and highly significant prolongation of left ventricular isovolumetric relaxation time (LVIRT) in FGR fetuses compared with controls (SMD, 2.48 (95% CI, 1.55–3.41); P < 0.00001; I 2 = 97%) (Figure 3d ).