Integrating machine learning and spatiotemporal transcriptomics to build a diagnostic model for osteosarcoma metastasis and to decipher the role of necroptosis genes.

Drug prediction and molecular docking based on ML core genes The top 10 potential anti-osteosarcoma metastatic drugs (AMG900, Ganetespib, etc.) were screened by drug-gene interaction network analysis, all of which showed highly significant statistical associations ( p < 0.001, adj- p = 0.01) (Fig. 7 A).

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