MTHFR functions as a metabolic checkpoint in NSCLC through SLC25A26-mediated SHMT2 inhibition.

Cell Death Dis · 2026 · PMC13434245 · PMID 42225644

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a nonsignificant trendno p-value reported

Furthermore, analysis of TCGA data indicated that high MTHFR expression was associated with improved overall survival (OS) and progression-free survival (PFS) in patients with LUAD, whereas only a nonsignificant trend was observed in patients with LUSC (Fig. 1G, H ).

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