Barely Significant
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Comparative risk of pneumonia and acute exacerbation between P-CAB and PPI use in patients with COPD and GERD.

NPJ Prim Care Respir Med · 2026 · PMC13434559 · PMID 42140971

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a favorable trendno p-value reported
A favorable trend with P-CAB in moderate–to–severe exacerbations was observed in patients with a lower comorbidity burden (CCI ≤ 1), with this pattern being more pronounced for severe exacerbations.

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