Detection and Validation of Influenza Virus Hemagglutinin Specific, Cross-Reactive, and Heteroclitic B Cells Induced by a Combination Vaccine Adjuvant.

Cytometry A · 2025 · PMC13435353 · PMID 41392330

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highly significantno p-value reported

Heteroclitic antibodies are postulated to be an intermediate in guiding cross-reactive antibodies/B cells to evolve towards binding the new mutated antigen in a live pathogen challenge, and as such, while small in size, they are likely to be highly significant and desirable.

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