highly significantp < 0.001
All two‐way interactions were highly significant ( p < 0.001 for each), and the three‐way interaction (AgeGroup × Season × ROI) was also significant ( F 2,1092 = 4.02, p = 0.018). 3.3 Estimated Marginal Means The EMMEANS for all significant effects and interactions are presented in Tables 3 and S1 , and Figure 3 .