Multi-omics integration unravels four molecular subgroups of corticotroph pituitary neuroendocrine tumours with distinct clinicopathological features.

To further solidify the molecular signatures of the subgroups 1–4, we performed RNA-based single-sample GSEA, which demonstrated robust and highly significant enrichment of the gene sets “stemness”, “synapse assembly”, “gonadotrophs” and “secretory vesicle”, respectively ( p < 0.001; Fig. 2d and Supplementary Data 5a–d ).

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