Baseline Liver Fibrosis Severity Predicts Superior HBeAg Clearance and Fibrosis Reversal following Peg-IFNα plus Nucleos(t)ide Analog Therapy in HBeAg-positive Chronic Hepatitis B Patients.

J Clin Transl Hepatol · 2026 · PMC13439103 · PMID 42559089

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an increasing trendno p-value reported

As shown in Figure 4 and Supplementary Table 5 , the HBeAg clearance rate exhibited an increasing trend with worsening fibrosis severity: Group 1 (no significant fibrosis) was 16.00% (12/75), Group 2 (significant fibrosis) was 30.00% (21/70), and Group 3 (advanced fibrosis/cirrhosis) was 40.74% (11/27).

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