Four sensitivity analyses confirmed the consistency of this Fusicatenibacter depletion trajectory: the signal remained highly significant when confined exclusively to advanced-stage patients (Coef = −5.66), when peri-chemotherapy systemic antibiotic, probiotic, and corticosteroid exposure was adjusted for (Coef = −5.16), in an antibiotic-depleted subset (Coef = −5.35), and after joint adjustment for baseline BMI, chemotherapy compliance, and surgical residual disease (Coef = −4.60).
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Chemotherapy-driven gut microbiota remodeling in ovarian cancer: a prospective longitudinal study.
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