Gut microbiome alterations are sex-dependently associated with brain abnormalities in a mouse model of Neurofibromatosis type I.

As in previous cohorts, there was a highly significant increase in brain weight relative to body weight in Nf1 +/- mice compared to +/+ controls (Fig. 4G : main effects – Genotype: p < 0.001; Sex: p < 0.001).

also in 115,300 other papers

Across behaviours, we found no significant sex effects, however it is interesting to note that the Genotype effect in the sociability index analysis was accompanied by a statistical trend for a Genotype x Sex interaction, and visual examination of the data confirms that the effect is mainly driven by a difference in male +/- animals.

also in 2,380 other papers