MiT fusions, TSC1-TSC2 divergence, and stem-like programs reveal distinct origins and vulnerabilities in PEComa.

Nat Commun · 2026 · PMC13442851 · PMID 42331846

Europe PMC DOI

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0.0680

closest p · 1.4× alpha

0.0680

boldest claim

The sentences

a trend toward significancep = 0.068so close (0.05 < p ≤ 0.1)

In this model, TP53 mutations remained independently associated with poorer DSS (HR: 3.33, 95% CI: 1.21–9.12, p = 0.019), whereas metastatic status showed a trend toward significance (HR: 2.95, 95% CI: 0.92–9.40, p = 0.068).

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