MLL4 protects cardiomyocytes against ischemia-reperfusion injury through STAT3-mediated mitochondrial function.

Furthermore, to clarify the temporal relationship between MLL4 and Stat3 activation, we measured the protein expression levels of total STAT3 and p-STAT3 in mouse heart tissues at different time points after MIRI, both total STAT3 and p-STAT3 protein levels showed an increasing trend starting from 3 h after reperfusion; however, the ratio of p-STAT3 to total STAT3 at each time point was not statistically different ( Fig.

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