Multiomics Integration Reveals Coexpression Regulatory Networks in Osteoporosis and Osteosarcoma.

Int J Genomics · 2026 · PMC13445564 · PMID 42564761

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a nonsignificant trendno p-value reported

Six hub genes—SP7/Osterix, RUNX2, BMP2, WNT5A, DKK1, and SOST—were examined by qRT‐PCR: SP7, RUNX2, BMP2, and WNT5A showed significant downregulation ( p < 0.01), whereas DKK1 showed significant upregulation ( p < 0.01) and SOST showed a nonsignificant trend toward upregulation under osteoporosis‐simulating conditions.

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