Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies.

However, for the equivalent TASK channel mutations described here (e.g., L122V and R131H), the overlapping expression patterns of TASK-1 and TASK-3 channels and their ability to form physiologically relevant heteromeric channels is also important because any differences in the activity of the heteromeric channels that result from these mutations could be highly significant.

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