Investigation of the role of delayed-type-hypersensitivity responses to myelin in the pathogenesis of Theiler's virus-induced demyelinating disease.

significant myelin‐specific DTH responses were not observed in mice tested at early times post‐infection (which had only recently developed clinical scores indicative of demyelinating disease), but highly significant ( P <0.001) responses were observed in chronically‐diseased animals (nine mice tested 36–48 weeks following infection).

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