Early resuscitation in the emergency room: dramatic effects that we should not ignore.

Crit Care · 2002 · PMC137388 · PMID 11940257

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This demonstrates that patients with severe sepsis/septic shock when first admitted to the emergency room of a large US hospital must have extremely low cardiac outputs, implying severe hypovolaemia, although there is also likely to be significant myocardial depression.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.