Bioinformatic analysis of an unusual gene-enzyme relationship in the arginine biosynthetic pathway among marine gamma proteobacteria: implications concerning the formation of N-acetylated intermediates in prokaryotes.

This is highly significant since the M. tuberculosis sequence was shown tocode for an enzyme whose functional characterization was reported while this paper was being prepared for publication: it displays acetylglutamate synthetase activity [ 10 ] and is required for the growth of its host as shown by previous high-density mutagenesis [ 15 ].

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