Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells.

In agreement with studies on fibroblast cell lines [ 51 , 52 ], we also noted that dexamethasone attenuated the release of gelatinase activity from PASMCs and this may be significant in the light of recent findings indicating that prednisolone selectively inhibits the proliferation of PASMCs from patients with idiopathic PAH [ 53 ].

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