First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats.

ansitional cell carcinomas of the renal pelvis and ureter and their precursors (dysplasias) in females treated at 100,000 ( p ≤ 0.01), 50,000 ( p ≤ 0.01), 10,000 ( p ≤ 0.01), 2,000 ( p ≤ 0.05), or 400 ppm ( p ≤ 0.05); and d ) an increased incidence of malignant schwannomas of peripheral nerves with a positive trend ( p ≤ 0.05) in males.

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