Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear.

Presentation of the hypothesis We performed PSI-BLAST [ 15 ] searches of the NCBI non-redundant database (~1,035,000 sequences) with conservative parameters (low complexity filter, expectation value 1, word size 2, inclusion threshold 0.0005) and found highly significant similarity between ~900 C-terminal amino acids of stereocilin and otoancorin (E-values at iterations 1 and 4 3e -14 and e -159 , respectively; Fig. 1 ).

also in 132,142 other papers