Limited beta2-adrenoceptor haplotypes display different agonist mediated airway responses in asthmatics.

The findings in this animal model of an increase in cholinergic sensitivity in the absence of chronic β 2 -AR stimulation and vice versa, fit in with our observation of a combination of apparent resistance to downregulation with respect to bronchoprotection (figure 1 and table 4 ) combined with the numerative (and borderline significant) largest degree of loss of bronchodilation (figure 2 and table 5 ) within genotype I/I.

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