Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks.

As before, we calculated the Spearman correlation for the ranked, but still unbinned, data and found that there is a relatively weak but highly significant correlation indicating that high connectivity genes are more evolutionarily conserved (R = -0.15, p value = 1.3 × 10 -19 , for the DD network; R = -0.22, p value < 1.4 × 10 -39 for ER network; and R = -0.18, p value = 4.0 × 10 -29 for the CC network).

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