highly significantp < 0.0006
Analysis of the frequency trend with age (in centenarian and control groups combined) for polymorphisms in APOC3 and CETP ( Figure 1 ), revealed a highly significant ( p < 0.0006; β = 1.89 [95% CI, 0.2–3.6]) monotonically increasing frequency trend for homozygosity for the APOC3 −641 C allele (CC)(rs2542052), and near-significance (β = 3.06 [95% CI, 0.33–5.8, p = 0.069]) for homozygosity for the CETP codon 405 valine allele (VV)(rs5882).