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Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina.

Int J Clin Pract · 2006 · PMC1448693 · PMID 16451297

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a statistical trendno p-value reported
The reduction in heart rate during exercise was associated with a significant increase in time to 1-mm ST-segment depression during ETT in a dose-dependent manner, and there was a statistical trend to improvement in time to limiting angina after just 2 weeks.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.