Effect of repaglinide on endothelial dysfunction during a glucose tolerance test in subjects with impaired glucose tolerance.

After 2 hours no significant difference from fasting baseline was observed when repaglinide was administered and borderline significance was observed in comparison to the control experiments.

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We do, however, not expect that the effect observed during repaglinide treatment is based on an opposing effect of higher insulin levels ameliorating the deleterious effect of hyperglycemia since regression analysis did not exhibit an association between changes of insulin and FMD during the oGTT whereas a highly significant correlation was observed between changes of glucose and FMD.

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