Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?

By contrast, the low dose of CRF (250 ng) failed to significantly enhance active lever pressing over vehicle despite the possibility of a slight trend (Bonferroni, p = 0.42, n.s), and by itself the 30-sec CS+ elicited merely a modest rise of only 50% over pre-cue baseline in lever pressing after vehicle microinjections, which was less than half the maximum drug-enhanced levels.

also in 4,078 other papers