Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.

However, the correlation of body weights of mice at 8 wk of age fed a low-fat diet to the change in fat mass from 8–12 wk of age was highly significant ( R = 0.364; P = 7.99 × 10 −05 ).

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In contrast to these almost insignificant associations between wean weights and adiposity, which were estimated by regression analysis to contribute only ~3% to the variance in adiposity after 4 wk on a high-fat diet, the association of adiposity with levels of SFRP5 mRNA was as high as 45% ( Figure 6 ).

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