Similar experiments have been carried out with P450 isozymes 2E1 and 2B1. The possible occurrence and role of FMO in the nervous system appears to be important not only because TDZ and several of its metabolites have similar biological properties and activation within the target tissue may be significant but also because the FMO has been shown to activitate phosphonates by metabolism to their oxons (43,87,88) and to carry out the sulfoxidation of phorate and other Environmental Health Perspectives * Vol 104, Supplement I * March 1996 102 PESTICIDES AND ENVIRONMENTAL HEALTH insecticides.
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Pesticides: an important but underused model for the environmental health sciences.
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