Genome-wide analysis of core promoter elements from conserved human and mouse orthologous pairs.

Out of the ten possible three-way interactions, two produced highly significant results: properly aligned BRE-Inr-MTE combinations are nearly four times as likely in the real dataset than in the randomized data (p = 4.1 × 10 -6 ), and the TATA-Inr-MTE combination is about 50% more likely in the real data versus the random data, which is also significant (p = 0.0042).

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The avoidance of BRE-TATA pairing is also an interesting trend, and is consistent with the findings of [ 28 ], who found that BRE tended to be found in TATA-less promoters.

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