Complexes of this size may not be significant since it is easy to create high density subgraphs of size 2 or 3, but becomes combinatorially more difficult to randomly create high density subgraphs as the size of the subgraph increases.
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An automated method for finding molecular complexes in large protein interaction networks.
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The sentences
Thus, it is expected that if a complex is found in a network with MCODE that matches a known complex, that the result would be highly significant.