Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289].

Again, when compared to an expected decline due the natural course of the disease, a marginally significant benefit of lutein would be found.

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In the model assuming a 6-week delay effect of lutein on VF, lutein had a highly significant effect in preserving VF and the mean log retinal area when participants were on lutein was 0.029 (95% CI: 0.012, 0.047, p-value:0.001) higher than when they were on placebo.

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