A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.

In this respect, cancers other than lung cancer, which are associated with tobacco consumption (such as oral cavity and bladder and esophagus cancers in Western countries), do not show as high a frequency of G to T transversions in p53 as seen in lung cancer (11). In summary, these analyses show that p53 mutations in lung cancer from smok- ers carry highly significant fingerprints of exposure to tobacco smoke components, in particular BaP.

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