Tumour necrosis factor-alpha stimulates HIV-1 replication in single-cycle infection of human term placental villi fragments in a time, viral dose and envelope dependent manner.

For the lowest dose of VSV-G pseudotyped HIV-1 (0.2 ng of p24 antigen/placental fragment), the effect of TNF-α on the viral replication was highly significant with a mR of 4.59 ± 0.91 (p = 0.002) after 120 hours postinfection and was not observed at earlier time points with a mR of 1.04 and 1.01 after 48 and 96 h, respectively (Figure 2A ).

also in 132,142 other papers

At 2 ng of p24 antigen of VSV-G pseudotyped HIV-1/fragment, the effect of TNF-α is only significant when data were analyzed globally for all the time points tested whereas at 20 ng of p24 antigen/fragment, the TNF-α effect is barely significant due to an already high basal replication without TNF-α (Table 1 ).

also in 875 other papers