The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses. Phase 1: use of a potent agonist and a potent antagonist to test the standardized protocol.

As was expected, the t -test approach was occasionally able to reach statistical significance when the Dunnett’s approach remained marginally insignificant.

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In laboratory 2, the LABC was marginally statistically significant by Dunnett’s approach using the starting body weights as the covariate, but not with the terminal body weights.

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