Duloxetine compared with fluoxetine and venlafaxine: use of meta-regression analysis for indirect comparisons.

The authors concluded that venlafaxine showed a favorable trend in remission and response rates compared with duloxetine, but that no significant between-drug differences were observed for dropout rates and adverse events.

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The odds ratio of the response factor varied from 0.81 to 0.95, favouring numerically duloxetine in every analysis and reaching borderline significance when the estimate was close to 0.81.

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This advantage is borderline significant when adjusting for duration (corresponding odds ratio 1.36).

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