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Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: a review.

Microb Cell Fact · 2006 · PMC1564409 · PMID 16600031

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may be significantno p-value reported
However, continuous extraction of samples increases contamination probability besides drop of volume may be significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.