Hormonal regulation of cytosolic free calcium and its functional consequences: the GH-cell model.

that is elicited by TRH. Using Quin-2 to monitor [Ca2+]i, we have identified two phases of change in [Ca2+]i induced by TRH (7). An acute spike occurs rapidly and decays with a half- time of about 7.5 sec toward the baseline [Ca2+]i. Within about 300 msec after addition of TRH, there is a highly significant increase in [Ca2+]i that peaks at 1 to 2 sec (8).

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