A new method for the analysis of cohort studies: implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure.

As these results show, the excess lung can- cer mortality is an increasing function of all three factors, and their associated test statistics, given in Table 5, are highly significant (one degree of free- dom chi-square tests for trend are 13.2 for exposure level, 49.1 for exposure duration, and 13.1 for age at initial exposure).

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