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Plummer-Vinson syndrome.

Orphanet J Rare Dis · 2006 · PMC1586011 · PMID 16978405

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a decreasing trendno p-value reported
A decreasing trend in the overall incidence of hypopharyngeal cancer in women was demonstrated, probably due to diminished prevalence of Plummer-Vinson syndrome [ 17 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.