In the meantime, we note that when we omit the dps -deleted strain from our analysis of the mean effect of secondary mutations, disruption type still explains a substantial, though marginally non-significant portion of overall variation ( F 1,9 = 3.663, P = 0.088).
Considering the mean response of genotypes, the main effect of disruption type was not significant, however, its interaction with environment was highly significant (table 2 and supplementary table 3 [see Additional file 1 ]).
However, there was a marginally significant effect of disruption type on the mean effect of secondary mutations (table 2 and supplementary table 6 [see Additional file 1 ]).