Using the nucleotide substitution rate matrix to detect horizontal gene transfer.

Although the difference in variance in GC content between HGT and non-HGT trees was highly significant ( P = 7 × 10 -25 by unpaired 2-tailed t-test, n = 100 per sample), the optimal single-variable classifier [ 74 ] gave 21% false positives and 0.5% false negatives.

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