Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.

Ther Clin Risk Manag · 2005 · PMC1661603 · PMID 18360537

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may be significantno p-value reported

Changes in liver size and blood flow, renal function, and drug–protein binding and distribution with aging may be significant variables that can affect drug metabolism and elimination.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.