Integrated siRNA design based on surveying of features associated with high RNAi effectiveness.

BMC Bioinformatics · 2006 · PMC1698580 · PMID 17129386

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highly significantno p-value reported

Two related features, G/C content is between 35 and 60% and G/C content is between 31.6 and 57.9% , however, were found to be highly significant in boosting the siRNA efficacy, agreeing with the common understanding that the effective siRNAs prefer a low-to-medium G/C content.

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